Urban seismic resilience is shaped not only by the structural integrity of buildings but also by the socio-economic vulnerabilities of the communities they shelter. In this study, we present a novel compiled dataset that bridges these two domains by integrating socio-economic indicators with engineering-based seismic resilience metrics for neighborhoods in Istanbul, a megacity with high seismic risk and socio-spatial inequality. Our hypothesis is that socio-economic disadvantage significantly influences whether people reside in earthquake-safe structures. To test this, we compiled and merged multiple publicly available datasets released by Istanbul Metropolitan Municipality, including the number of households receiving social aid, socio-economic status (SES) scores, and structural vulnerability parameters derived from seismic risk assessments. The dataset allows for a nuanced, data-driven understanding of post-earthquake recovery capacity across Istanbul’s neighborhoods. Initial findings reveal that areas with lower SES scores correlate with higher expected recovery time and cost, suggesting a compounded vulnerability. Beyond its research value, the dataset provides practical utility for municipalities, civil protection units, and policy-makers aiming to prioritize interventions. It enables targeted resilience enhancement strategies and facilitates simulations of neighborhood-level risk under various seismic scenarios.