The objective of this research is to develop a frame configuration that ensures effective energy dissipation and displacement control during seismic events, offering a viable alternative to conventional pendulum-type isolation systems. The proposed solution is evaluated in terms of structural effectiveness, practical feasibility, economic viability, and post-earthquake repairability. To align with commonly adopted structural systems and construction practices, particularly in the precast industry, a frame system was designed using a combination of pinned and semi-rigid beam-to-column connections. These connection types are not only compatible with dry construction methods, which are widely preferred for their ease of assembly and reduced construction time, but also offer potential advantages in seismic performance when appropriately detailed. Recognizing the critical role of connection behavior in seismic response, the study includes a dedicated investigation of the beam-to-column joints through both experimental testing and advanced numerical simulations. This dual approach aims to capture the cyclic behavior, energy dissipation capacity, and potential failure mechanisms of the connections under seismic loading, thereby providing robust input for performance-based design. Although current industry trends often prioritize rapid assembly and cost-efficiency—sometimes favoring traditional dry construction solutions even at the expense of increased material consumption, alternative configurations with enhanced seismic efficiency and minimal post-earthquake intervention are being considered. This study contributes to this emerging direction by proposing and validating an innovative connection system that balances construction practicality with improved seismic resilience.