Seismic reliability analysis (SRA) is a powerful tool able to combine seismic hazard and structural fragility for computing the probability of failure of a specific damage state of interest. In this work, a SRA has been applied to a specific case study of an open spandrel RC arch bridge located in North-eastern Italy, adopting as suitable engineering demand parameters for both the ductile and fragile failure mechanism of the columns between the RC arches and the RC beams grillage. Collapse seismic fragilities are computed for each structural element and, finally, the bridge seismic reliability is computed in a system reliability-based format.