In the last years, the use of Multi-Temporal Interferometric Synthetic Aperture Radar (MT-InSAR) technique for Structural Health Monitoring (SHM) has taken hold. Compared to traditional monitoring methods, the monitoring process through MT-InSAR techniques involves a series of advantages, as the possibility to perform back-analysis and the possibility to extend the monitoring to the surrounding area, that make it a very cost-effective tool. On the other hand, some drawbacks still need to be fully overcome, as the issues related to the geocoding of the measurement points and the noisiness in the time series. In this article, the application of MT-InSAR monitoring to a case study is presented. The structure of interest is the Scrovegni Chapel in Padova, one of the most important structures in the Italian cultural heritage, that contains numerous frescos executed by Giotto. Processing images acquired by COSMO-SkyMed constellation, the deformation of the area surrounding the chapel was estimated, by means of spatial interpolation algorithms. In addition, time series referred to measurement points located on the rooftop were analyzed and compared to the environmental data (temperature and humidity) acquired by physical sensors previously installed.