In the present paper a preliminary characterization of the dynamic behavior of the Sarcophagus of the Spouses at the National Etruscan Museum of Rome by advanced digital videos analyses is illustrated. This activity was carried out within the MONALISA project funded by Lazio Regional Government and the Italian Ministry of University and Research, which focuses on the development of a base-isolation system for statues in order to reduce potential damage due to traffic and earthquakes. The Museum is located in the city center, near busy roads, tramways and an underground train line, which transfer relevant vibrations to the floor of the exhibition room of the statue directly resting on the ground. These vibrations were measured by seismographs and analyzed to interpret the base excitation to the Sarcophagus. Given the high vulnerability of the Sarcophagus, no instrumentation could be placed on its surface, so that conventional contact sensors could not be used to characterize its dynamic response. Consequently, non-contact video-based techniques were applied. In particular, high-speed and high-resolution video camera footage was recorded. The videos were analyzed by advanced algorithms derived from the motion magnification method, which is a video signal elaboration method able to enormously amplify the tiniest movements of the acquired objects. From a proper analysis of the magnified videos, a preliminary estimate of the main frequencies of the Sarcophagus could be proposed. These frequencies and their association to different portions of the Sarcophagus will be used to calibrate the numerical models and to optimize the design of the base-isolation system. The used digital video analysis technique is also discussed in terms of its many advantages and its application criticalities.