The 2016 seismic sequence that struck Central Italy, with its three mainshocks and numerous aftershocks, caused widespread damages to building heritage. Among the buildings that suffered damages, schools are considered relevant structures from multiple points of view. Educational institutes, indeed, host children and young people during their training years in facilities that are often old and realized without recent safety Standards becoming, therefore, non-resilient, nor robust structures towards multiple natural hazards. In this paper, an empirical predictive model, known in literature and already used for the evaluation of potential post-earthquake scenarios to cultural heritage, is applied to school buildings located into the seismic crater of the Marche region. Moreover, a database containing information regarding the geolocation of individual buildings, no. of floors, the floor surface, the construction period, the structural type and the potential presence of landscape or hydrogeological constraints, has been realized with reference to the schools of the Marche region. Once collected information, also regarding observed damages and recorded seismic intensities to schools during the 2016 Central Italy earthquake, the parameters of the probabilistic damage model are estimated. The predictive response model is finally applied, with reference to a single event, by evaluating consequences on schools belonging to the database.